Any-maze track plot report3/29/2024 By combining behavioral analysis with electroencephalogram (EEG) recordings we describe a characteristic pattern composed of two distinctive EEG waveforms, Phase 1 and Phase 2, that map onto behavioral arrest and the HTR respectively, with the same temporal separation. In response to administration of the potent and highly selective 5-HT 2AR agonist 25I-NBOH in mice, we observe a disorganization of behavior which includes frequent episodes of behavioral arrest that consistently precede the HTR by a precise interval. While the HTR provides a key behavioral signature, less is known about the meso level changes that are induced by 5-HT 2AR activation. Hallucinogens induce the head twitch response (HTR) in rodents, which is the most commonly used behavioral readout of hallucinogen pharmacology. The 5-HT 2AR subtype has been shown to be central to hallucinogen action, yet the precise mechanisms mediating the response to 5-HT 2AR activation remain unclear. Perception, emotion, and mood are powerfully modulated by serotonin receptor (5-HTR) agonists including hallucinogens.
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